Dave Wacker

From Genome@Yale

office: SHM I-147
phone: 203-785-7504

Education

• B.S., Physics, Summa cum Laude, Univ. of Minnesota, Minneapolis (2001)
• M.S., Physics, Cornell University, Ithaca, NY (2004)
• Ph.D., Biophysics, Cornell University, Ithaca, NY (2006)
• Medical Student, Yale University, New Haven, CT (2006-present)

Professional Activities

• Member of the Biophysical Society (January 2001 - January 2005)
• Reviewer for the Yale Journal of Biology and Medicine (September 2006 - Present)
• Member of the American Medical Association (September 2006 - Present)
• Section editor for original submissions, Yale Journal of Biology and Medicine (May 2007 - April 2008)

Clinical Experience

• Volunteer assistant at the Cayuga Medical Center Emergency Department, Ithaca, NY (February 2005 - December 2005)
• Volunteer clinical assistant at the Columbus House Shelter, New Haven, CT (September 2006 - January 2008)
• Leadership board member and volunteer coordinator for the YSM/Columbus House clinical assistant volunteer program (January 2007 - January 2008)

Honors

• University of Minnesota Presidential Scholar (1997-2001)
• Cornell University Graduate Fellow (2001-2002)
• NIH/Cornell Molecular Biophysics Trainee (2003-2004)
• Etta S. Chidsey Award in Cancer Research Recepient (2007)

Presentations

• Wacker D.A., Brower-Toland B., Fulbright R.M., Lis J.T., Kraus W.L., Wang M.D. (2004). Structure and Stability of Tailless and Acetylated Nucleosomes as Studied by Optical Tweezers. Abstract, 48th Annual Biophysical Society Meeting. Baltimore, MD. February, 2004.
• Wacker D.A., Kim M.Y., Kraus W.L. (2005). Imaging PARP-1-associated chromatin structures. Abstract, 49th Annual Biophysical Society Meeting. Long Beach, CA. February, 2005.
• Wacker D.A., Hope K.M., Kim M.Y., Kraus W.L. (2005). Imaging PARP-1 associated chromatin structures by atomic force microscopy. Abstract, Mechanisms of Eukaryotic Transcription, Cold Spring Harbor, NY. August, 2005.
• Wacker D.A., Hope K.M., Kim M.Y., Kraus W.L. (2006). Imaging PARP-1-associated chromatin structures by atomic force microscopy. Abstract, Keystone Meeting on Epigenetics and Chromatin Remodeling in Development. Keystone, CO. January, 2006.
• Kraus W.L., Wacker D.A., Kim M.Y., Zhang T., Hope K.M., Krishnakumar R., Frizzell K.M. (2006). NAD+-dependent modulation of chromatin structure and transcription by poly(ADP-ribose) polymerase-1 (PARP-1). Abstract, East Coast PARP Meeting 2006. Quebec City, Quebec. May, 2006. (Oral Presentation)
• Kim, T.H., Wacker, D.A. (2007). Genome-wide function of CTCF. CSHL Mechanisms of Eukaryotic Transcription Meeting.

Publications

• Brower-Toland B.*, Wacker D.A.*, Fulbright R.M., Lis J.T., Kraus W.L., Wang M.D. (2005). Specific contributions of histone tails and their acetylation to the mechanical stability of nucleosomes. J. Molec. Biol. 346: 135-146. *equal contribution
• Wacker D.A., Frizzell K.M., Zhang, T., Kraus W.L. (2007). Regulation of chromatin structure and transcription by poly(ADP-ribose) polymerase-1: Possible targets for drug based therapies. In: Kundu T.K. and Dasgupta D. (eds.) Chromatin and Disease. Subcellular Biochemistry Series, vol. 41. Springer.
• Wacker D.A.*, Ruhl D.D.*, Balagamwala E.H., Zhang T., Kraus W.L. (2007). The DNA binding and catalytic domains of poly(ADP-ribose) polymerase 1 cooperate in the regulation of chromatin structure and transcription. Mol Cell Biol. 27:7475-85. *equal contribution
• Wacker, D.A., Kim, T.H. (2009). From Sextant to GPS: Twenty-Five Years of Mapping the Genome With ChIP. Journal of Cellular Biochemistry 107:6-10.